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Des sources du savoir aux médicaments du futur

 | 
Jacques Fleurentin
, 
Jean-Marie Pelt
, 
Guy Mazars

2. Études chimiques et pharmacologiques

Artemisia annua: a plant with antiplasmodial activity for local production in the tropics?

Markus Müller, Innocent Balagizi, E Wemakor, S M Li, E Mechler et L Heide

Texte intégral

  • 1 German Institut for Medical Mission 72076 Tuebingen (Germany)

1Note portant sur l'auteur1

  • 2 Centre de Recherche en Sciences Naturelles Lwiro (République Démocratique du Congo)

2Note portant sur l'auteur2

  • 3 Pharmaceutical Institute Tuebingen University (Germany)

3Note portant sur l'auteur3

  • 4 Pharmaceutical Institute Tuebingen University (Germany)

4Note portant sur l'auteur4

  • 5 Pharmaceutical Institute Tuebingen University (Germany)

5Note portant sur l'auteur5

  • 6 Pharmaceutical Institute Tuebingen University (Germany)

6Note portant sur l'auteur6

  • 1 (1985) The Peoples Republic of China, Pharmacopoeia, Vol. 1, Beijing: The people's Health Publishe (...)

7Artemisia annua L. is one of the oldest well documented medicinal plants and is listed in the Chinese pharmacopoeia as a remedy against malaria1.

  • 2 VAN AGTNAEL M.A., EGGELTE T.A., VAN BOXTEL C. J. (1999) Artemisia drugs in the treatment of malari (...)
  • 3 ZHAO S-S, ZENG M-Y. (1985) Studies on the analysis of Qinghaosu by high-pressure liquid chromatogr (...)

8Artemisinin, extracted from Artemisia annua, is a well established compound in the treatment of malaria2. However, very few data are available about the efficacy of the traditional tea preparation of Artemisiae annuae herba so far.In the current investigation, Artemisia annua L. was successfully cultivated in Central Africa. The leaves of this plant contained 0.63 - 70 % artemisinin, as determined by HPLC3, and 40 % of this artemisinin could be extracted by simple extraction using infusion with boiling water.

9With permission of the local health authorities and with informed consent of the patients, two pilot studies were carried out in order to observe the clinical antiplasmodial efficacy of these preparations. Doses (5 g dried leaves per day) were corresponding to the recommendations of the Chinese Pharmacopoeia. In the first trial 25 semi-immune patients with parasitaemia and symptoms typical for malaria showed a rapid decrease of the parasite density on day 2 and 4 of the treatment. On day 6, thick blood films of 21 of the 25 patients (84 %) were negative.

10In another trial 44 of 48 patients (92 %) were free of parasites in the thick blood films after a five days' course with the tea preparation. This was accompanied by a significant improvement of the subjective symptoms in 37 patients (77 %). No severe side-effects were seen. In our opinion, these results justify further examinations of the antiplasmodial potential of Artemisiae annuae herba preparations. Further studies would need to put special emphasis on the observation of possible recrudescence after initial improvement.

  • 7 Shown are means and 95% Confidence Intervals

Reduction of parasite density in thick blood films of 25 patients with malaria7

Notes

1 (1985) The Peoples Republic of China, Pharmacopoeia, Vol. 1, Beijing: The people's Health Publisher.

2 VAN AGTNAEL M.A., EGGELTE T.A., VAN BOXTEL C. J. (1999) Artemisia drugs in the treatment of malaria: from medicinal herb to registered medication, TiPS, 20: 199-205.

3 ZHAO S-S, ZENG M-Y. (1985) Studies on the analysis of Qinghaosu by high-pressure liquid chromatography and spectrometry, Planta Medica, 51: 233-7.

Notes de fin

1 German Institut for Medical Mission 72076 Tuebingen (Germany)

2 Centre de Recherche en Sciences Naturelles Lwiro (République Démocratique du Congo)

3 Pharmaceutical Institute Tuebingen University (Germany)

4 Pharmaceutical Institute Tuebingen University (Germany)

5 Pharmaceutical Institute Tuebingen University (Germany)

6 Pharmaceutical Institute Tuebingen University (Germany)

7 Shown are means and 95% Confidence Intervals

Table des illustrations

Légende Reduction of parasite density in thick blood films of 25 patients with malaria7
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