Table des matières
Hugues de Thé
Liz Libbrecht (trad.)
Oncology: From Empiricism to Integrative BiologyInaugural Lecture delivered on Thursday 8 January 2015
- The first approaches
- “Experimental cancer”
- Epidemiology: a first approach to human cancers
- The discovery of oncogenes
- Antioncogenes or tumour suppressors
- How antioncogenes are inactivated?
- Cooperation and multistage transformation
- How to treat tumours?
- The pioneering role of leukaemia in the understanding of cell transformation
- Acute promyelocytic leukaemia
- PML/RARA, the driver of transformation and therapeutic response
- Arsenic opens a new path
- How do arsenic and retinoic acid degrade PML/RARA?
- Proof by mice
- Antagonism or synergy?
- Exception or precursor?
- Prospects for the future: categorizing and targeting
- Cell heterogeneity
- Chance in biology and medicine
- Public health and medical research